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NNMT inhibition increases availability of NAD+ and influences metabolic processes, allowing the body to burn more calories while suppressing additional glycogen and fat deposits

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Diagnosis integrates clinical symptoms, B12 levels (or active B12/MMA/homocysteine where appropriate), antibody results, and exclusion of other causes

This placebo controlled study in 24 elderly individuals showed that a single dose of an NAD+ booster before exercise improved fatigue index, physical recovery and muscle function

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