More realistic scenario: FDA approval 2028, commercial launch Q3-Q4 2028, shortages through early 2029, stable availability mid-2029
GLP-1, together with GIP, is responsible for the incretin effect, since it binds to GLP-1 receptor in -cells in the pancreas leading to an increase in intra-cellular Ca and a subsequent insulin secretion in response to glucose (Reference Vilsbll and Holst11)
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The genetic component of pancreatitis can be roughly divided into two areas: common variants that increase susceptibility to acute pancreatitis and then rare mutations that cause hereditary chronic pancreatitis
It is not appropriate for patients with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or severe gastrointestinal disease
In this Ask Me Anything (AMA) episode, Peter focuses the discussion on two topics getting a lot of attention recently