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Avoid exceeding prescribed doses to reduce side effects

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The treatment significantly improved stool frequency and overall quality of life, compared with a placebo treatment ( Although senna is generally considered safe, it can lead to adverse effects when used for long periods at high dosages

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Neurotoxicity of Zinc in Ischemia Tonder and colleagues (9) conducted the first study providing indirect evidence for the toxic translocation of zinc from presynaptic neurons into selective postsynaptic neurons during the experimental paradigm of global ischemia