In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight
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Endogenous production of GSH can be negatively affected by genetic factors, malnutrition, protein insufficiency, hypochlorhydria, and increased exposure to toxins in the environment (Minich 2019)
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Additionally, we considered articles from the reference lists of relevant studies and literature known to be pertinent by the authors