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Patients with Crohn's disease, ulcerative colitis, or severe IBS should work closely with their gastroenterologist before starting semaglutide

Medical evaluation needed: Persistent constipation beyond 8 weeks without improvement despite trying relief strategies

For the serum lipid, although only 5 trials provided sufficient data, the improvements in semaglutide group were still observed both on total cholesterol (WMD -030, 95% CI -052 to -008

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doi: 10.1016/j.jsbmb.2018.04.008