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[389] As shown in Table B-G1, participation in one-sided models is lower in PY 2025 (29 percent of ACOs) compared to PY 2022 (41 percent of ACOs), and PY 2023 and PY 2024 (33 percent of ACOs for each PY)

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Retatrutide works like other weight loss and type 2 diabetes medications, but what makes it different is that it can target three receptors (triple agonist) at once: GIP (gastric inhibitory polypeptide) receptor GLP-1 (glucagon-like peptide-1) receptor GCG (glucagon) receptor This unique triple-action may make it more effective than GLP-1 and GLP-1/GIP medications

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