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2011;9:e0142

doi:10.1016/j.freeradbiomed.2012.02.026, PMID: 22387197 Martn SF, Sawai H, Villalba JM, Hannun YA (2007) Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism

NNMT nicotinamide N-methyltransferase, Gene ID 4837 (11q23.2, 8 exons, EC 2.1.1.1)

Each enzyme and transporter is modeled using an experiment-derived rate equation featuring its concentration, key kinetic properties, and effects of inhibitors and activators (where applicable and relevant)

The treatment is very safe, and excess B12 is simply excreted by the body

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