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Over the next five years, the marketplace will only grow more crowded: cheaper generics, oral pills replacing injections, and an escalating marketing war as companies expand indications from diabetes and obesity into sleep apnea, fatty liver disease, even addiction

Can compounders add ingredients like B12 to GLP-1 formulations to reduce nausea and still comply with regulations

Orforglipron has the potential to redefine the maintenance phase of obesity care, says Fatima Cody Stanford, MD, MPH, an obesity medicine physician-scientist and an associate professor of medicine and pediatrics at Harvard Medical School in Boston, who was not involved in the trial

GLP-1 RAs augment insulin secretion after meals and inhibit glucagon production from pancreatic alpha cells at hyper- or euglycemia

Beyond the regulatory milestone, the expansion reflects a broader commercial strategy