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Nitrous oxide, a commonly used anesthetic, oxidizes and inactivates vitamin B 12 , thus inhibiting both of the vitamin B 12 -dependent enzymes, and can produce many of the clinical features of vitamin B 12 deficiency, such as megaloblastic anemia and neuropathy

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Safety, Side Effects, and Monitoring Common side effects include: Nausea Vomiting Diarrhea Constipation Abdominal discomfort These usually lessen with dose titration

Gum disease, for instance, has been shown to make diabetes harder to manage

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