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In the 24-week, placebo-controlled factorial study of initial therapy with JANUVIA in combination with metformin, the incidence of hypoglycemia was 0.6% in patients given placebo, 0.6% in patients given JANUVIA alone, 0.8% in patients given metformin alone, and 1.6% in patients given JANUVIA in combination with metformin

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Intervention duration influences the cumulative process from molecular adaptations to tissue-level pathological improvements

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Combining dual-agonist peptides with other appetite suppressants like phentermine is generally not recommended due to increased side effect risk without clear additive benefit