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Establishment of normal concentrations of NAD and Glutathione forms in Whole Blood Next, we applied our profiling methodology to define human population values of the six redox metabolites using frozen whole blood samples from 299 anonymous healthy donors (191 females and 108 males, aged 18-70 years) provided by the Finnish Blood Service BioBank and 38 healthy in-house volunteers

However, a postmortem study showed that GSH and GSH/GSSG were significantly decreased in the brains of ASD patients relative to controls 18 , suggesting that markers of glutathione metabolism may have parallel changes between central and peripheral in ASD

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Next, to test the role of system x c - in response to combined GLUT1 and GCL inhibitors, we evaluated the response to the drug combination in xCT knockdown cells