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This D-amino acid substitution introduces conformational rigidity within the pharmacophore core (His-D-Phe-Arg-Trp) and significantly increases binding affinity across melanocortin receptor subtypes compared to both -MSH and MT-1

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doi:10.1016/j.solener.2011.08.012 Perks S, Robertson S, Haywood A, Glass B (2012) Clozapine repackaged into dose administration aids: a common practice in Australian hospitals