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In this review, the new class of antihyperglycaemic agents with incretin effect, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 inhibitors (IDPP-4), and novel sodium-glucose cotransporter 2 inhibitors (ISGLT2) that increase renal glucose excretion will be analyzed

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This limitation emphasizes the importance of employing diverse experimental models to enhance our understanding of Semas therapeutic implications in a broader, more clinically relevant context