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The growth plates close and the metaphysis and epiphysis fuse into one bone

Signalling roles of mammalian phospholipase D1 and D2

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By evading this sequestration, IGF-DES is able to engage the IGF-1 receptor (IGF-1R) more directly, making it a uniquely valuable research tool for studying IGFBP-independent IGF-1 receptor signalling

Indicated in agricultural animals for prevention and treatment of: tetany ( tetany during pregnancy and lactation periods, transit tetany, grass sickness, etc)