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In murine models of diabetic nephropathy, exogenous BMP-7 or upregulation of endogenous BMP-7 led to increased expression of Ski-related novel protein N (SnoN), a key negative regulator of the TGF-1/Smad pathway [75, 76]

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Pregnant women aged 18 y who presented for prenatal care before or at 14 wk of gestational age (as judged by the date of the last menstrual period) were eligible for inclusion

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