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We found that PA-S14 promotes mitochondrial biogenesis via LKB1-AMPK-PGC-1 signaling pathway, which protects against renal TECs cell senescence, renal fibrosis in various CKD models, such as unilateral ureteral obstruction (UUO), unilateral ischemia-reperfusion injury (UIRI), adriamycin nephropathy and 5/6 nephrectomized model (Liu et al., 2022a) (Table 1)

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7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents

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However, he says he can highlight to patients which products are available and, with their full consent and understanding that these peptides are not for human consumption, he is able to recommend peptide therapy