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Meanwhile, exposure to sevoflurane might also lead to iron-induced neurotoxicity in the hippocampus and cognitive dysfunction by upregulating NMDA receptors and enhancing divalent metal transporter 1 (DMT1)-mediated iron upregulation and iron release from lysosome (Wu J

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The sustained-release drug delivery facilitated by microneedle systems can streamline drug administration, achieve therapeutic concentrations within a specified time frame, and minimize potential systemic toxicity [185]

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