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Additionally, the causal relationship between EMT and ferroptosis is poorly resolved: existing data only confirm mutual association, but it is unclear whether EMT-induced FTH downregulation is a primary trigger of ferroptosis or a secondary response to ferroptotic tubular injury

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These cases highlight the central challenge: ensuring exceptional safety and tolerability for long-term use

Purity decreased only slightly over the 28-day period (from approximately 98% to ~96%), which is fully within acceptable limits and expected under prolonged exposure to elevated temperatures

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