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Key storage recommendations include: Keep refrigerated until ready to use Store unopened pens in the original carton in the refrigerator Never freeze Discard any tirzepatide that has been frozen Protect from light Keep the pen in its original carton Monitor temperature Avoid exposure to temperatures above 86F (30C) Track room temperature storage If storing unrefrigerated, use within 21 days Inspect before use Check for discoloration, particles, or cloudiness Patients traveling with tirzepatide should use insulated medication travel cases with ice packs (ensuring the medication does not come into direct contact with ice)

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The glutathione peroxidase 4 (GPX4)-glutathione (GSH) system is considered one of the classic antioxidant systems against ferroptosis [38, 39]

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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling