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Another study reached similar conclusions, noting that when taken together, HRT helps preserve muscle and reduce belly fat, while semaglutide (Wegovy) lowers appetite and insulin sensitivity
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The rapid glucose load may also cause blood sugar fluctuations, particularly in patients taking concurrent diabetes medications like insulin or sulfonylureas, which could compound feelings of nausea or discomfort
RALDH2, retinaldehyde dehydrogenase 2
74 In a comparative study in obese male mice of vertical sleeve gastrectomy (VSG), semaglutide treatment, and controls, both interventions improved glycemic control and reduced body weight, but VSG significantly decreased energy expenditure and induced notable bone loss, whereas semaglutide preserved BMD over six weeks