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It may play a role in defending the body against harmful bacterial overgrowth and even promote the growth of beneficial organisms in the gut microbiome, which in turn affects a variety of disease processes.2 While theres still a lot to uncover about berberines mechanisms of action, researchers do know it impacts a host of medical conditions, such as: Diabetes3 Insulin resistance4 High cholesterol5 High blood pressure6 Candida overgrowth7 Metabolic syndrome8 41 Polycystic ovarian syndrome (PCOS)9 Ulcerative colitis10 Irritable bowel syndrome (IBS)11 Nonalcoholic fatty liver disease12 It might even be a potential cancer preventive or adjunctive therapy

Brain 135 , 17511766 (2012)

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The common age-onset of both vulvar and penile melanoma is that they both affect elderly individuals from the sixth and seventh decades of life (51,52)

PMID 3298579