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We tailor the treatment regimen based on several factors such as the severity of the deficiency, the patients overall health condition, and their capacity to absorb Vitamin B12

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Localized to the plasma membrane, FSP1 utilizes NAD(P)H to reduce CoQ10 to CoQ10H 2 or ubiquinol, which acts as a lipophilic radical-trapping antioxidant that can effectively interrupt the lipid peroxidation chain reaction, thus establishing a defense line on the plasma membrane independent of the GPX4GSH system (Mao et al., 2021

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2004 [cited 2021 Mar 11];79:72747