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That part is fairly straightforward

Thalidomide is associated with edema, sinus bradycardia, venous thromboembolism, and lenalidomide is associated with hypersensitivity myocarditis, and high-dose interleukin-2 is associated with fulminant myocarditis

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Therefore, relatively high laser power is required for confocal imaging, which can consequently cause phototoxicity to live cells, especially with excitation at 405 nm (ref

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In anti-TNF inadequate responder patients with RA, RTX can reduce the levels of ESR, CRP, and RF, and improve clinical symptoms (85)