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In trials of semaglutide for weight management, up to 44% of patients reported nausea and about 24% reported vomiting

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Tirzepatide activates both GLP-1 and GIP pathways simultaneously, producing greater appetite suppression and weight loss than single-pathway medications in clinical trials

In type 2 diabetes, postprandial GLP-1 secretion may be reduced , leading to an impaired insulin response