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Novo Nordisk developed it as a long-acting version of the naturally occurring hormone, engineered with specific amino acid substitutions that extend its duration of action from minutes to days

In addition to increases in insulin secretion and synthesis, GLP-1 suppresses Glc secretion, slows gastric emptying, reduces food intake, and promotes beta-cell proliferation

The story is more nuanced than simple calcification, though that is certainly part of it

Influence of baseline severity on antidepressant efficacy for anxiety disorders: Meta-analysis and meta-regression

Robust human RCT data is absent

This often resembles telogen effluvium, a temporary shedding pattern that can follow rapid weight loss, illness, surgery, childbirth, crash dieting or nutritional stress