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The pharmacokinetic differences between short-acting and long-acting analogues have profound implications for the mode of action, efficacy, and tolerability of these compounds

Maintaining the correct conformation, concentrations, and post-translational modifications of HIV-1 proteins in experimental settings is particularly challenging

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doi: 10.1186/s10194-021-01271-1, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 10.Biscetti L, Cresta E, Cupini LM, Calabresi P, Sarchielli P

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Care should be taken to not interpret these findings as those seen within a superficial spreading melanoma, and to not make the diagnosis of melanoma in this population