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A clinical trial published in The New England Journal of Medicine showed that adults who took semaglutide, combined with lifestyle changes, lost significantly more weight than those who relied on diet and exercise alone

Urgent same-day assessment by a multidisciplinary foot service is required for any foot ulcer, signs of infection, or a red, hot, swollen foot (which may indicate Charcot arthropathy)

These may indicate anaphylaxis or severe hypersensitivity requiring immediate treatment

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Bottom Line In a head-to-head phase 3 trial of nearly 1,700 adults with type 2 diabetes, the once-daily pill orforglipron beat oral semaglutide on the measures that matter most, lowering HbA1c by about 2.2% and body weight by about 9.2%, along with better blood pressure and cholesterol

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