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Regarding the intracellular cholesterol homeostasis, cholesterol efflux was increased by EX-4 and AICAR and was further increased by their co-treatment (Figure 2G)

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Those with a long half-life (weekly exenatide, efpeglenatide, liraglutide, semaglutide, albiglutide and dulaglutide) produce a sustained activation of rGLP1, resulting in a greater reduction in HbA1c, basal glycemia and body weight and would have fewer gastrointestinal side effects

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The Nrf2 signaling pathway responds to oxidative stress by upregulation of antioxidants like glutathione (GSH) to compensate the stress insult and re-establish homeostasis