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Additionally, this topic has been investigated through clinical studies, with METAOD005 being a prominent example

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Issues like nausea and constipation tend to decrease with time

Phase 1 studies involving ex vivoedited T cells (e.g., TCR knockout to reduce graft rejection) using lentiviral vectors are ongoing, but definitive efficacy data have not yet been published [139]

At the same time, GIP has been linked to increased insulin secretion and improved pancreatic beta-cell function following diet-induced weight loss