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In a systematic review of randomized clinical trials, 6.5% of those using a GLP-1RA discontinued it due to adverse events versus 3.6% of those on placebo (16), but these rates appear to be higher in observational studies where factors associated with discontinuation were an age of 65 years or older and GI adverse events with treatment (21)
I am very interested to find out if other people who have experienced this on the 8th day. occurrence have gotten their second shot and, if so, if they had any or different reactions
doi: 10.1016/j.bbiosy.2022.100047
Vitamin injections are administered intramuscularly and provide slower, sustained nutrient release over time
They included 12 SGLT2i trials with 73,238 participants, of whom 3,065 were on a GLP-1 RA: they found that the benefits of SGLT2i on MACE were consistent regardless of background GLP-1 RA use (HR = 0.81 in patients receiving GLP-1 RA vs HR = 0.90 in those not receiving GLP-1RA) with no significant heterogeneity (p = 0.31)