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Unlike classical type 2 diabetes marked by insulin resistance, this phenotype, estimated to affect 25 million people in LMICs, is characterized by severe pancreatic -cell dysfunction with substantial deficits in insulin secretion, yet insulin sensitivity is preserved, and autoimmunity or ketoacidosis are absent [144]

Maintaining nuclear zinc homeostasis requires dedicated mechanisms, including import and buffering systems

IV vitamin therapy may be useful in certain circumstances and for specific people