semaglutide hypoglycemia risk Frontiers Unlike some earlier studies, this

Gabrielli et al., 2011

doi: 10.3390/ijms25021024

Hyperandrogenemia, altered leptin and other adipokine concentrations, and impaired granulosa cell function all contribute to menstrual irregularities by causing hypothalamic dysfunction, decreased folliculogenesis, and lower luteal progesterone levels [135,136,137]

Another bonus is muscle protection

The relative potency at each receptor target has been described in early preclinical and clinical publications, with retatrutide demonstrating particularly strong GLP-1 and GIP receptor activity alongside moderate glucagon receptor activation, though precise potency ratios remain subject to ongoing characterisation

PMID: 41069706 PMCID: PMC12504844 Weisberg, Fraser