If GI symptoms worsen during a taper step-down rather than improve, that is unusual and warrants clinical re-evaluation for an alternate cause
& Saade, E
Adopting a personalized approach to supplement selection is also critical
Impure peptide preparations can introduce experimental confounders, as degradation products or synthesis byproducts may have their own biological activities or interfere with receptor binding assays
doi:10.1111/dom.12924 MacLean PS, Wing RR, Davidson T, Epstein L, Goodpaster B, Hall KD, Levin BE, Perri MG, Rolls BJ, Rosenbaum M, Rothman AJ, Ryan D
These medications mimic that hormone at higher, sustained levels, acting on receptors in the hypothalamus to reduce hunger and increase satiety