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In preclinical models, inhibiting this receptor has been shown to mimic some of the physiological effects of endurance exercise
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Right heres a timeline primarily based on different factors: 1
The L-371,257 powder was dissolved in 10% dimethyl sulfoxide (DMSO) in phosphate buffered saline (PBS)
Inhibiting DPP-4 enzyme activity The enzyme dipeptidyl peptidase-4 (DPP-4) rapidly breaks down natural GLP-1, giving it a half-life of only 1-2 minutes