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The critical insight is that fat loss is often still occurring during a plateau

& Itzkowitz, S

Careful observation for digital changes is necessary during VYVANSE treatment

Head-to-head comparative trials and studies of combination regimens are needed to establish optimal treatment sequencing and identify which patients benefit most from each approach or from their combination

Ongoing development of targeted, sustained-release systems and multimodal combination strategies holds promise for improving long-term clinical outcomes and expanding access to individualized treatment

Weight Regain After Discontinuation Is the Rule, Not the Exception Without addressing: Insulin sensitivity Muscle preservation Nutrient status Lifestyle structure Most patients experience partial or full weight regain after stopping GLP-1 therapy