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Rodents overexpressing USP22 or lncRNA PART1 were well resistant to I/R-induced oxidative stress and cardiac injury, which may be partly attributed to the elevated GSH content in the myocardium [251, 252]

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Hyperbaric oxygen therapy (HBO), a promising adjuvant for heatstroke-induced liver injury, synergizes with conventional therapy to mitigate hepatic dysfunction (evidenced by reduced ALT, AST levels) [85, 86], via anti-inflammatory effects (regulating immune cell balance, suppressing pro-inflammatory cascades), antioxidative actions (enhancing tissue oxygenation, reducing ROS-mediated lipid peroxidation), and improved coagulation (protecting hepatic microcirculation) [85, 86]

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These are typically administered either intramuscularly (IM) or intravenously (IV), depending on the product and the individuals needs

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