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Excluding the few exceptions where methionine may act as a redox sensor (e } : CS1 maint: multiple names: authors list (link) "Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age"

We have included substrate activation (the Hill term on the right) and found that if we omitted this substrate activation then the cytochrome oxidase reactions did not produce enough NAPQI at high overdoses

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Telomere Shortening : Telomeres, the protective caps on the ends of chromosomes, shorten as we age, leading to cellular aging

Thiols are known metal chelators