The researchers assessed the change in body weight from baseline within each trial and subgroup and they also carried out a mediation analysis to differentiate between direct and indirect effects of semaglutide on weight loss, the latter of which was mediated by nausea or vomiting
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Many obese patients have low self-esteem and unrealistic views about how much weight loss is possible
Semaglutide helps to keep blood sugar levels stable by inhibiting the release of glucagon, especially after meals
Nausea is the most frequently experienced side effect, potentially affecting a significant proportion of patients, particularly during the initial weeks of therapy and during dose escalation periods