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The Sec within catalytic motif serves as the active site
Small molecules targeting JAK/STAT and PDE4 pathways such as tofacitinib and apremilast present oral alternatives, though often with reduced efficacy compared to biologics and notable side effects like gastrointestinal intolerance or lipid changes [99]
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Watch for signs like bleeding gums, nosebleeds, or unusual bruising
positions 1, 3, and 5)
J Inorg Biochem 2019;195:1119
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