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Furthermore, the TGA was the only NRA amongst comparable regulators with no accelerated or adaptive approval pathway options, therefore lacking the necessary flexibility to prioritise vital products for unmet needs [2]

This is mechanistically distinct from neurotransmitter modulators requiring sustained plasma levels

Since glycolysis inhibition can ameliorate inflammatory abnormalities associated with peripheral inflammation [118], targeting glycolysis might represent a conceivable strategy to mitigate aberrant inflammation in the prodromal stage of PD

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These are usually dose-dependent and most pronounced during titration