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It usually increases rapidly in size to several centimetres and is characterised by acanthosis and spongiosis of the affected epithelium with dendritic melanocytes dispersed throughout the thickness of the epithelium, with a mild inflammatory cell infiltrate in the superficial lamina propria [11, 13, 34]

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Arbutin encapsulation within the transfersomes was resulted in augmented skin permeation and enhanced depigmenting effectiveness of the loaded drug (Wen et al., 2006b)