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1,2 In healthy humans, the complex biochemical interplay between organs maintains metabolic homeostasis

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In addition, estrogens can inhibit the expression of BA metabolic enzymes, especially phase II enzymes (such as hydroxysteroid sulfotransferase 2a1, Sult2a1), which in turn decreases the metabolism of bile acids, leading to an increased levels of unconjugated and hydrophobic bile acids in hepatocyte, and a decrease in bile flow (Zamek-Gliszczynski et al., 2006

The goal is observation , not evaluation

Certain benefits fade faster than others