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The starting dose is 0.6 mg daily and titrates up to a maximum daily dose of 1.8 mg daily

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J Clin Pharm Ther (2021) 46(1):99105

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The ECD of GCGR, on the other hand, is in an extended conformation with the -sheet module covering the orthosteric TMD pocket and the inhibitory mAb1 engaging the orthosteric ECD-binding site directly