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Individuals who lose very large amounts of weight (often 80100+ pounds) may require extensive surgical body lifts, circumferential procedures, or multi-stage operations

The first, as Adams' experienced, is the "dam breaking phenomenon, which is what you'd expect from taking a ton of laxatives," Goldstein said

Nonetheless, there remains an ongoing need for additional medicines, particularly those with a distinct mode of action that could be used independently or in combination with the current incretin-based therapeutics

P., Fernandes, P

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