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Human trials showed that in people with high-risk features, treatment with minocycline reduced in 6 months the risk of conversion to MS, decreased lesion volume, and showed the absence of new enhancing lesions, but this effect did not last beyond 24 months of study (Preiningerova et al., 2022)

Rather than changing the DNA sequence itself, methylation influences whether certain genes are switched on or off, allowing different cells to perform specialised functions despite containing the same genetic information

10.1016/j.biopha.2017.11.016 57 GillettM

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Scaling concepts in omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis

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