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Clinical Trials & Approval The clinical development phase begins with Investigational New Drug (IND) submissions and proceeds through Phase I trials for safety and pharmacokinetics, Phase II for dose optimization and early efficacy, and Phase III for large-scale confirmation of therapeutic benefits

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Proper hand hygiene and controlled glove use further support skin barrier function and minimize irritation [20, 80]

Nat Rev Cancer (2012) 12(8):56471