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In a subject already harboring an occult malignancy, chronically supplying a pro-migratory, pro-angiogenic signal is a theoretically unfavorable intervention, and no long-term animal study has been conducted to exclude that risk

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-selective activity underlies its positive inotropic effects, producing increased ventricular contraction with relatively modest increases in heart rate and minimal changes in peripheral vascular resistance

Studies examine its influence on signaling pathways involved in cell renewal and adaptive responses

Human clinical data is lighter but growing, and clinical use in sports medicine has been widespread

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