It has been possible to map the incretin function in humans in some detail owing to the availability of receptor antagonists for both hormones, namely exendin 9-39 for the GLP-1 receptor and the amidated GIP fragment GIP 3-30 amide for the GIP receptor [2]
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Tips: Avoid foaming cleansers and alcohol-based toners Use non-comedogenic, pH-balanced moisturizers Consider topical zinc, niacinamide, green tea extract Functional Medicine Testing for Acne Patients A comprehensive acne workup may include: Integrative Acne Treatment Timeline Month 12: Begin gut and hormone support Identify and remove food/environmental triggers Start peptides or key anti-inflammatory supplements Month 34: Optimize detox and blood sugar Reintroduce clean skincare Monitor symptom response and retest if needed Month 5+: Shift to maintenance Support microbiome and hormonal rhythm Consider peptides for immune support or scar repair When Medications Make Sense In some cases, medications may be helpful alongside a functional approach: Spironolactone : For androgen-driven acne Metformin : For PCOS with insulin resistance Topical retinoids : To prevent pore clogging Isotretinoin : For severe cystic acne unresponsive to all other therapies Functional providers will always aim to minimize long-term pharmaceutical reliance , but occasionally integrate them strategically
