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Status Not FDA-approved for human use
Light-activated transcription of immediate-early genes such as c-fos and JunB (165,166) causes activation of PER1 gene transcription as well as modification of the acetylation pattern of histone tails
However, AZD3965 is known to deplete the level of intracellular glutathione [28], the thiol-containing tripeptide -L-Glu-L-Cys-Gly (GSH), an antioxidant known to coordinate to transition metal drugs [28, 41, 42]
Notably, those early reports touted BPC-157 as free of side effects with a very safe profile, even at high doses