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Yoshida T, Niho S, Toda M, Goto K, Yoh K, Umemura S,

doi: 10.1056/NEJMra2026131 77 FakhrolmobasheriM.Mazaheri-TehraniS.KieliszekM.ZeinalianM.AbbasiM.KarimiF.et al

Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions

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To further confirm the findings, pseudotime analysis revealed that clusters expressing high monocyte markers served as root cells, and macrophages differentiated through the intermediate cluster 3 to produce the activated mature innate immunologic cells or the mature alveolar macrophages (Fig